Fantasy Football Week 2 DFS Optimal Lineup 

NFL Week 2 is upon us! The Desai Guys have all the DFS picks you'll need to win big. Stay tuned to LAFB for all your fantasy football needs.

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The Desai Guys Look To Amon-Ra St. Brown To Have A Big Day In Fantasy Football Photo Credit: Jeff Nguyen | Detroit Lions
The Desai Guys Look To Amon-Ra St. Brown To Have A Big Day In Fantasy Football Photo Credit: Jeff Nguyen | Detroit Lions

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The 2022 NFL season is just a day away from kicking off Week 2 and we are here to bring you the best lineup for your daily fantasy football teams. Whether it’s Aaron Rodgers, Alvin Kamara, or Kyle Pitts, there are plenty of question marks out there about effectiveness.

You can check out the article below to find out some of the best players to add to your roster that will help you win with the best Week 2 fantasy football roster! All prices are courtesy of Draft Kings, be sure to check them out for your best daily fantasy football plays. 

Daily Fantasy Football QB Pick: Carson Wentz vs. Detroit Lions – $5,800 

Don’t mistake this for being a believer in Carson Wentz and the Washington Commanders quite yet but for this price, it’s well worth the risk early in the season. Ron Rivera and the Commanders had the full Wentz experience in Week 1 with just enough good plays to make you a believer but also a fair amount of poor ones to leave some doubt. His four-touchdown performance was surprising and likely not sustainable but against a Lions defense that allowed Jalen Hurts to put up nearly 22 fantasy football points, he’s worth the risk. 

Other QB options: Derek Carr vs. Arizona Cardinals ($6,200), Joe Burrow vs. Dallas Cowboys ($6,600) 

Daily Fantasy Football RB Pick: Javonte Williams vs. Houston Texans – $6,500 

While Javonte Williams’ rushing performance left a lot to be desired against the Seahawks (7 rushes for 43 yards), his receiving stats were absolutely phenomenal. 11 catches for 65 yards tells us that even if he can’t get it done on the ground, the Broncos will get him involved through the air. As Williams faces off against a Texans team that struggled to stop the Colts run game, this is an excellent fantasy football value for the back that could produce RB1 numbers for you at a RB2 price. 

Other RB options: Darrell Henderson vs. Atlanta Falcons ($5,700), James Robinson vs. Indianapolis Colts ($5,600) 

Daily Fantasy Football WR Pick: Amon-Ra St. Brown vs. Washington Commanders – $6,500

At the risk of sounding like a used car salesman, this value is an absolute steal. Many were doubting if Amon-Ra St. Brown could carry over his effectiveness given the number of weapons the Lions added or had returning to this offense but he proved those doubts were unfounded in Week 1. Not only did he rack up eight catches, including one for a touchdown, but Jared Goff targeted him 12 times against the Eagles. This Commanders defense, while not a bad one, certainly has a weaker secondary than most NFL teams so expect that production to continue. 

Other WR options: Robbie Anderson vs. New York ($5,300), Jahan Dotson vs. Detroit Lions ($4,200)

Daily Fantasy Football TE Pick: O.J. Howard vs. Denver Broncos ($3,000) 

Sometimes the most obvious pick is the best one. O.J. Howard finally showed the promise that many were hoping for him when he was selected in the first round of the 2017 NFL Draft. While it is unreasonable to expect him to repeat his Week 1 performance with multiple scores, it is certainly within the realm of possibility that he is frequently targeted by Davis Mills. The Texans are facing a tall order in Week 2 as they look for their win playing an angry Broncos team looking to prove themselves as well. In all likelihood, the Texans are going to be passing it often and those targets have to go to someone other than Brandin Cooks

Other TE options: Pat Freiermuth vs. New England Patriots ($4,400),. Hayden Hurst vs. Dallas Cowboys ($3,600) 

Daily Fantasy Football FLEX Pick: Jerry Jeudy vs. Houston Texans ($5,600) 

To say that Jerry Jeudy has had an up-and-down career might be a bit of an understatement. However, he certainly looked like a receiver worthy of a first-round pick last week. While his four catches left something to be desired, his seven targets certainly are telling that those numbers are poised to increase when playing in a smoother game. As mentioned before, the Broncos are going to come into this game motivated and that means plenty of scoring opportunities for the third-year receiver. 

Other FLEX options: Michael Thomas vs. Tampa Bay Buccaneers ($5,800), Antonio Gibson vs. Detroit Lions ($6,200)  

Daily Fantasy Football D/ST Pick: Pittsburgh Steelers vs. New England Patriots ($2,800)

There is nothing more certain in life than death, taxes, and the Pittsburgh Steeler’s defense. The fact that the team is an underdog heading into this game is an absolute mystery. The Steelers defense and special teams are almost single-handedly responsible for their win against the Bengals last week. Minkah Fitzpatrick, Myles Jack, and Alex Highsmith all showed that they can succeed even if T.J. Watt is out for this game. On the far side of the spectrum, the New England Patriots offense looked absolutely miserable against the Miami Dolphins and there’s little optimism for improvement. Expect the Steelers “upset” here and take advantage of it with their defense as well. 

Other D/ST options: Cleveland Browns vs. New York Jets ($3,700), Jacksonville Jaguars vs. Indianapolis Colts ($2,300)

The Desai Guys Look To Amon-Ra St. Brown To Have A Big Day In Fantasy Football Photo Credit: Jeff Nguyen | Detroit Lions
The Desai Guys Look To Amon-Ra St. Brown To Have A Big Day In Fantasy Football Photo Credit: Jeff Nguyen | Detroit Lions